据悉，欧盟2021年4月9日，评估欧盟食品安全局就一种食品酶制剂异麦芽糖合酶（isomaltulose synthase）的种异安全性评价发布意见。

据了解，麦芽酶这种食品酶制剂是糖合由Serratia plymuthica strain Z12A生产的。经过评估，安全专家小组得出结论，欧盟该食品酶制剂在预期的评估使用条件下不会引起安全问题。部分原文报道如下：

The种异 food enzyme isomaltulose synthase (sucrose glucosylmutase; EC 5.4.99.11) is produced with Serratia plymuthica strain Z12A by BENEO‐Palatinit GmbH. The food enzyme is used only in the form of an immobilised preparation of non‐viable cells for the production of isomaltulose. Residual amounts of total organic solids (TOS) are removed by the purification steps applied during the production of isomaltulose consequently, dietary exposure was not calculated. Genotoxicity tests did not indicate safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1,011 mg TOS/kg body weight (bw) per day, the highest dose tested. Similarity of the amino acid sequence of the enzyme to those of known allergens was searched and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood of such reactions to occur is considered to be low. based on the data provided, the use of an immobilised food enzyme and the removal of TOS during the production of isomaltulose the Panel concluded that this food enzyme preparation does not give rise to safety concerns under the intended conditions of use.

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相关链接：异麦芽糖，欧盟食品安全

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